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Deadline for applications: 2019-07-01

1 Assistant Professor and 2 Junior Faculty Positions at Department of Mathematics, University of California, Riverside (USA)

The first position will be filled at the Assistant Professor level with the starting date of July 1, 2019:
https://www.mathjobs.org/jobs/jobs/12811

Applications are welcome from those with strong interdisciplinary background in any area of applied mathematics. Preference will be given to applicants in Computational Modeling of Fluids and Stochastic Modeling with Applications.

Two additional positions are open for Joint Postdoctoral Fellowships/ Junior Faculty Positions for Emerging Scholars in Applied Mathematics. While these will also be filled at the level of Assistant Professor, they provide an exciting opportunity for highly-qualified emerging scholars who are preparing to transition into the professoriate, offering an initial year of postdoctoral fellowship research support and training anywhere in the United States in 2019-2020 prior to their move to UC Riverside on July 1, 2020 as a tenure-track faculty member.
https://www.mathjobs.org/jobs/jobs/12814

Applications are welcome from those with a strong interdisciplinary background in any area of applied mathematics. Preference will be given to applicants in Computational Modeling of Fluids, Stochastic Modeling with Applications, Optimization, Multi-scale Modeling in Biology and Computational Methods for Nonlinear PDEs.

Please contact: Mark Alber
https://mathdept.ucr.edu/


Deadline for applications: 2019-03-24

PhD positions and fellowships at International Max Planck Research School for Evolutionary Biology, Ploen, Germany

The International Max Planck Research School for Evolutionary Biology is offering up to 10 PhD positions and fellowships. The graduate school is dedicated to highest level of research and training in all areas of contemporary Evolutionary Biology.
It is a joint initiative of the Max Planck Institute for Evolutionary Biology, the University of Kiel and the Helmholtz Center for Ocean Research Kiel (GEOMAR).
The school offers an internationally competitive research environment with state of the art facilities. The participating groups are working on a broad variety of scientific topics including molecular, behavioral, theoretical and organismal approaches.
The graduate program starts with a rotation period of three months followed by a PhD project of three years including seminars, courses and workshops. The language of the graduate school is English.
Financial support is provided throughout the program. To obtain further information about our PhD program and application details, please visit our website at http://www.evolbio.mpg.de/imprs.
Note that only online applications via the link on our homepage are being processed. Please do not send any other type of application by regular mail or email as they will be rejected. Well-motivated and highly qualified students from all countries are welcome to apply. A Master of Science degree or a Diploma as well as a strong interest in Evolutionary Biology and flexibility in the research project are prerequisites for entering the program.

We are looking forward to your online application for a PhD project in the beautiful landscape of Northern Germany.

The deadline for applications is March 24, 2019. The personal interviews will be held from June 17 to 20 and the program itself starts on September 16, 2019.

Please contact: Kerstin Mehnert
https://www.evolbio.mpg.de/imprs


Deadline for applications: 2019-05-15

PhD Studentship at MRC Centre for Regenerative Medicine, Edinburgh, UK

Fully-funded PhD studentship: Mathematical modelling of multicellular interactions in stem cell regulation and tissue regeneration.

We are looking for an ambitious and motivated postgraduate candidate to design a mathematical framework for understanding complex multicellular interactions in regeneration. This project will use tools from dynamical systems theory, statistical physics/stochastic processes, and Bayesian inference. A particular focus will lie on finding distinguishing hallmarks of particular regulatory principles, and from these to generate predictions that could be tested in collaboration with experimental labs.

The successful applicant will be based in the group of Dr Linus Schumacher (http://crm.ed.ac.uk/research/group/computational-biology-cell-populations) at the MRC Centre for Regenerative Medicine and will also be working closely with Dr Ramon Grima (http://grimagroup.bio.ed.ac.uk/).

The Schumacher group develops mathematical models of cell populations in development and regeneration, working closely with experimental collaborators with the long-term aim to formulate principles that apply to multiple biological systems, gain insight into misregulation in disease, and inform improvements to regenerative therapy. The Grima group has extensive expertise in the building and theoretical analysis of stochastic models of intracellular dynamics and cell-cell interactions.

For further details, see https://www.findaphd.com/phds/project/mathematical-modelling-of-multicellular-interactions-in-stem-cell-regulation-and-tissue-regeneration/?p101556

Please contact: Linus Schumacher
https://www.findaphd.com/phds/project/mathematical-modelling-of-multicellular-interactions-in-stem-c


Deadline for applications: 2019-03-31

Postdoc - Yeast systems and synthetic biology at Institut Pasteur and Inria, Paris, F.

Postdoc "Yeast systems and synthetic biology", Institut Pasteur and Inria, Paris

We are looking for a highly motivated quantitative biologist with a strong interest for interdisciplinary research to join our team. We combine quantitative systems biology with applied mathematics and control theory for cell engineering. Our long-term goal is to develop integrated, model-driven hardware/software/lifeware platforms for the rational engineering of microbial cell populations.

Keywords: genetic engineering, quantitative biology, bioproduction, cell physiology, optogenetics, smart lab.

The Project:
There are nowadays, over 400 recombinant peptides and proteins on the market, and many others are undergoing clinical trials. Host cells are required to produce large amounts of the heterologous protein. To match this demand, cellular resources needs to be reallocated. This may imbalance various physiological equilibria and cause deleterious effects on the recombinant product and on the host cell. The cell production rate and the cell growth rate might both be impacted. In the majority of the applications, this problem is addressed -at least partly- by dissociating growth from production: a first phase focuses on biomass production and a second phase focuses on product synthesis.

Our objective is to develop strategies that are more considerate for the host cell. We aim at demanding only the maximum that the cell can stand over long durations. Regulation and automated feedback are at the core of these strategies. We will envision both external and internal feedback approaches. For the former, one has to sense and quantify the level of (synthesis / folding / secretion) stress of the cell and dynamically adapt the induction level accordingly. For the latter, one has to engineer regulation circuits in which stress levels mitigate protein synthesis rates.

The candidate will employ methods like modular cloning, optogenetics, automated bioreactors enabled for real-time control, and quantitative modeling to understand single cell physiology and develop host-aware approaches for cell engineering.

Qualifications:
Candidates should have a PhD in biology with expertise in systems biology and/or synthetic biology. He or she should be capable of using modern genetic engineering methods and produce and analyze quantitative data. Experience with yeast engineering would be a significant asset.

We are primarily searching for a creative mind wiling to develop his or her research in line with the lab directions. Funding for a relatively long stay is available (up to 4.5 years). We also expect that he or she will have a leading role in the team and take an active part in student supervision. So team spirit is essential and seniority would be appreciated.

Work environment:
Our group, InBio, is a joint initiative between Inria and Institut Pasteur. Inria is a French national institute dedicated to research in computer science, control and applied mathematics, and promoting scientific excellence and technology transfer. The Institut Pasteur is a world-renowned non-profit private foundation dedicated to biomedical research and the fight against infectious diseases. It offers access to top-notch experimental platforms and strong support for innovation.

InBio is an interdisciplinary research group, combining experimental and computational biology in the same lab. We combine systems and synthetic biology approaches with control and active learning methods and stochastic and statistical modeling frameworks. Current applications include (i) the real-time control of gene expression using optogenetic and chemical stimulations in various systems (e.g. gene expression in yeast and bacteria, toggle switch in bacteria), (ii) the optimization of protein production through the preservation of host cell physiology or through engineered cell specialization, and (iii) the characterization of collective antibiotic resistance in ESBL-producing bacteria. We also develop platforms to automate experiments.
The group consists of scientists with diverse backgrounds (mathematics, physics, computer science, and biology) and nationalities (French, German, Spanish, Montenegrin, and Indian). The spoken language is English. We are located on the vibrant campus of Institut Pasteur in the heart of Paris.

Applications are accepted immediately and candidates will be considered until the position is filled. The successful applicant will be hired on a two-year contract with possible extensions and a competitive salary.

Applications should include a CV, a brief text describing your current research and career goals and how you could contribute to our research program, and contact information of references.

Please contact: Gregory Batt
http://bit.ly/InBioPasteur


Deadline for applications: 2019-03-31

Postdoc Smart microscopy for single-cell biology at Institut Pasteur and Inria, Paris, F.

We are looking for a highly motivated biophysicist or engineer with a strong interest for interdisciplinary research to join our team. We combine quantitative systems biology with control theory and applied mathematics for cell engineering. Our long-term goal is to develop integrated, model-driven hardware/software/lifeware platforms for the rational engineering of microbial cell populations.

Keywords: fluorescence microscopy, optogenetics and digital micromirror devices, microfluidics, optimal experimental design and reactive microscopy, synthetic biology.
The Project:
Our group is developing a design/build/test/learn approach for strain engineering. Models play a central role and are iteratively used, in combination with learning, to guide the design and construction of engineered yeast strains and the design of maximally-informative experiments.
The main tasks of the postdoctoral candidate will be to (i) develop a reactive microscopy platform that integrates the optimal experimental design algorithms, (ii) use them to characterize at the single cell level engineered cells constructed in the lab, and (iii) orient model developments. The candidate will have a pivotal role to showcase the effectiveness of design, build, test and learn strategies.

Qualifications:
Candidates should have a PhD in physics or engineering with expertise in microscopy and quantitative biology. He or she should be capable of developing an advanced microscopy platform combining hardware and software for reactive experiments. So, good programming skills are essential. Knowledge of microfluidics or of quantitative, mechanistic mathematical modeling in systems biology will be appreciated. Given the high interdisciplinarity of the lab, the will to exchange knowledge (transmit and learn) with other lab members will be an essential asset.

Work environment:
Our group, InBio, is a joint initiative between Inria and Institut Pasteur. Inria is a French national institute dedicated to research in computer science, control and applied mathematics, and promoting scientific excellence and technology transfer. The Institut Pasteur is a world-renowned non-profit private foundation dedicated to biomedical research and the fight against infectious diseases. It offers access to top-notch experimental platforms and strong support for innovation.
InBio is an interdisciplinary research group, combining experimental and computational biology in the same lab. We combine systems and synthetic biology approaches with control and active learning methods and stochastic and statistical modeling frameworks. Current applications include (i) the real-time control of gene expression using optogenetic and chemical stimulations in various systems (e.g. gene expression in yeast and bacteria, toggle switch in bacteria), (ii) the optimization of protein production through the preservation of host cell physiology or through engineered cell specialization, and (iii) the characterization of collective antibiotic resistance in ESBL-producing bacteria. We also develop platforms to automate experiments.
The group consists of scientists with diverse backgrounds (mathematics, physics, computer science, and biology) and nationalities (French, German, Spanish, Montenegrin, and Indian). The spoken language is English. We are located on the vibrant campus of Institut Pasteur in the heart of Paris.

Applications are accepted immediately and candidates will be considered until the position is filled. The successful applicant will be hired on a two-year contract with possible extensions. Salary will be based on experience.

Applications should include a CV, a brief text describing your current research and career goals and how you could contribute to our research program, and contact information of references

Please contact: Gregory Batt
http://bit.ly/InBioPasteur


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